The Next Generation of Biologic Medicine

We are now using the secretions of stem cells and growth factors, increasing their availability, and decreasing the complexity required to incorporate the patient’s own stem cells themselves into the treatment process.

The Organicell™ Difference

Isolating the beneficial signals given out by stem cells and using them rather than the stem cells themselves are the next generation as a therapy. Other cells will react to these messaging signals and will change their behavior accordingly. There is a tremendous therapeutic potential of extracellular vesicles, particularly exosomes.

THE MESSENGERS- SEE HOW EXOSOMES WORK

Extracellular vesicles (EV’s) consist of exosomes and microvesicles, which are released directly from the cell membrane. EV’s can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. EV’s are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV’s may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation.

GROWTH FACTORS & CYTOKINES

Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors. Cytokines are proteins that are produced by numerous cell types and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation. Target cells of growth factors and cytokines are mesenchymal, epithelial and endothelial cells. A complex network of growth factors and cytokines guides cellular differentiation and regeneration in all organs and tissues. These molecule can act in a paracrine or an autocrine or fashion.

PARACRINE and AUTOCRINE SIGNALING

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to autocrine signaling which travel considerably longer distances (via the circulatory system).

Amniotic Fluid Allograft

Organicell™ Flow is a sterile filtered amniotic fluid allograft intended for patient treatment.
Organicell Flow Amniotic Fluid contains many components crucial to tissue regeneration including :

• EXOSOMES derived from MSC’s – Over 52.6 billion per ml
• Growth Factors
• Cytokines
  Chemokines
• Hyaluronic Acid
• microRNA
• Secretomes
• Lipids
• Carbohydrates
• Electrolytes

Organicell Flow is Sterilized to Enhance Safety

Quality Compliance & Donor Screening
Organicell Flow is procured and processed in the United States according to standards and regulations established by the American Association of Tissue Banks (AATB) and the United States Food & Drug Administration (FDA).
Donor ethics and non-reactive FDA approved serological screening includes:
• Donor consent prior to collections
• HBsAG (Hepatitis B Surface Antigen)
• HBcAb (Hepatitis B core antibody)
• HCV (Hepatitis C antibody)
• HIV 1/11-Ab (HIV Nucleic Acid Test)
• HCV NAt (HCV Nucleic Acid Test)