Acid Blocker Medications Increase Risk of Fractures, GI Infections

A newly published study by the Mayo Clinic  shows that regularly taking the acid blocker medications known as PPIs (protein pump inhibitors)  causes an imbalance in the bacteria that line the gut and  creates  risk for infections like pneumonia, clostridium difficile, and it also causes mineral and vitamin deficiencies and  an increase in the rate of bone fractures.

Lead author of the study  John DiBaise, M.D., a Mayo Clinic gastroenterologist reviewing current knowledge explained. “Evidence has been mounting for years that long-term use of proton pump inhibitors poses increased risks for a variety of associated complications, but we have never really understood why. What this study does for the first time is demonstrate a plausible explanation for these associated conditions.”

There are trillions of bacteria in the gut which are beneficial to the body, and make up our natural “microbiome”. This gut “microbiome” plays a role in many bodily functions from digestion to immune system regulation to vitamin synthesis.
Proton pump inhibitors are used in the treatment of acid reflux and  ulcers, and  include the commonest generic names, omeprazole, and pantoprazole . Although originally approved for short term use, they are commonly taken on a long-term, chronic basis.Prolonged use of PPIs have been shown in many studies to cause to nutrient deficiencies;  among others, iron and vitamin B12 deficiencies, low magnesium, osteoporosis and the consequent bone fractures,  intestinal bacterial overgrowth. pneumonia, and clostridium bacterial infections.

Dr DiBaise cautions, “We’re not saying people should stop taking their regular antacids. What we are saying is that the medical and research communities should consider these medications in the context of the patient’s microbiome. This is an area that needs further study.”

This study should caution all potential users of these medications  to seek a nutritional dietary approach to controlling heartburn. Simple ideas not necessarily easy for people to do, would be controlling the size of portions eaten at one time, maintaining  a proper body weight and avoid eating at night within a couple of hours of going to bed. If these are not enough, natural remedies like licorice root extract, slippery elm,  aloe juice, and ginger extract or tea, may be helpful in avoiding pharmaceuticals for treatment.  Taking pre and probiotics  seems advisable as well.

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at [email protected]

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