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The most common conditions that cause illness and death are cardiovascular disease, and cancer. Inflammatory and metabolic conditions promote these illnesses and many others. Each of these four herbal compounds have been shown to benefit the mechanisms by which these and many other illnesses develop: CURCUMIN – BERBERINE – ASHWAGANDA – POMEGRANATE
They can be taken individually, or as a powerful longevity combination
CURCUMIN
Curcumin is one the most researched plant substances in the world. It is derived from Turmeric which has been used for centuries for its medicinal properties. Curcumin has been shown to have anti-inflammatory and antioxidant properties. Chronic inflammation in the body is known to be the mechanism by which many of the most common diseases develop. As a consequence of curcumin’s antioxidant and anti-inflammatory properties it may also be antimutagenic (anti-tumor growth), and thus an anticancer agent [7,8].Ongoing research continues to define the mechanisms that explain its beneficial effects on a wide array of conditions. Oxidative stress has been implicated in many chronic diseases, and pro-inflammatory actions may cause the pathological processes involved in Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, epilepsy, cerebral injury, cardiovascular disease, hyperlipidemia, metabolic syndrome [10], allergy, asthma, bronchitis, colitis, arthritis, renal ischemia, psoriasis, diabetes, obesity, depression, and fatigue. There are many studies which have confirmed curcumin’s antimicrobial activity[5,6], and its use in pain [11], and inflammatory conditions [9]. It has been shown to benefit the kidneys [14],and degenerative eye conditions [12,13] as well.
Tumor necrosis factor α (TNF-α) is a marker of inflammation in many diseases. Curcumin blocks TNF activation which occurs as a result of different inflammatory stimuli [10].Curcumin’s effect on free radicals is carried out by several different mechanisms. It can scavenge for free radicals [25]. It modulates the activity of enzymes such as GSH, catalase, and SOD which neutralize free radicals [21,22]. Curcumin is a lipophilic compound, making it an efficient scavenger of free radicals. Curcumin improves systemic markers of oxidative stress [23]. It can increase the activities of the antioxidant SOD (superoxide dismutase).
BERBERINE
Berberine has been shown to be beneficial for a variety of health problems. (Li et al., 2018; Neag et al., 2018; Belwal et al., 2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697704/
Berberine lowers blood sugar, (Liang et al., 2019), improves prediabetes (Lou et al., 2011), and lowers cholesterol (Li et al., 2016). It may also be beneficial for mild cognitive impairment (Kumar et al., 2016) . Finally, there is evidence that berberine has anti-cancer properties. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376565/
Berberine for Neurodegenerative and Neuropsychiatric Disorders
Berberine has a protective effect on the central nervous system. It can help a wide array of problems such as depression, anxiety, and Alzheimer’s disease [25,26]. After ingestion Berberine crosses the blood–brain barrier enhancing its ability to help in treating neurological disease[23,24]. Berberine decreases the production of kynurenine, a substance which is metabolized to neurotoxic compounds, and disturbs neurotransmission [3,29]. Berberine has also been shown to inhibit the reward effect in drug abuse with substances such as cocaine, narcotics and alcohol. [23,30,31]. Berberine may have antidepressant actions. It impacts the brain-derived neurotrophic factor—binding protein pathway, a known antidepressant mechanism crucial to the antidepressant action of some medications.
Berberine’s Anti-Cancer Properties A study documenting the anticancer activity of berberine [32]was first published in 1986. Subsequent studies demonstrated the cytotoxic activity of berberine towards many specific cancer cell lines such as promyelocytic leukemia cell lines [33,34], uterine cancer [35,36], lymphocytic leukemia , myelomonocytic leukemia [37], and myeloid leukemia cell lines [38]. Non leukemic cancers such as large intestine cancer [39,40], bladder cancer [41], hepatoma, non-small cell and Lewis lung cancer cell line cytotoxic abilities have also been demonstrated. Activity against astrocytoma (brain cancer) and melanoma cell lines have also been seen [44],[45]. Berberine’s cytotoxicity towards cancer cell lines is dependent on the dose and time.
POMEGRANATE
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Pomegranate can help many of the most common health problems that people suffer from.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8595036/#B106
They published another overview of its potential preventative health benefits
https://www.nccih.nih.gov/health/pomegranate
- Heart and circulatory disease– likely due to its antioxidant properties
- Gastrointestinal system – inflammatory bowel disease
- Diabetes– Insulin resistance – lowers blood glucose readings
- Central nervous system – ischemic stroke, and
- Reproductive system – heavy menstrual bleeding, and nausea and vomiting during pregnancy
- Rheumatic disorders – Rheumatoid and osteoarthritis
- Dermatologic disorders – Ultraviolet-induced pigmentation
- Periodontitis and gingivitis – related to its anti-inflammatory and antimicrobial activities.
Studies have shown that pomegranate may play a role in prevention of so many disease:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007340/
Coronary Heart Disease There have been a number of studies which have documented the improvement in a variety of risk factors and markers of coronary and circulatory disease. After one year of drinking Pomegranate juice for one year a significant reduction in the thickness of the inner lining of the carotid artery was documented as well as a lowering of the “bad ” cholesterol-LDL
Diabetes One randomized, double-blind, placebo-controlled trial on 40 diabetic patients who suffered a heart attack took pomegranate extract for one month. That reduced both fasting blood glucose readings, and lowered Hgb A1C levels [82].
Oxidative Stress Oxidative stress plays a role in the development of cardiovascular disease. A number of studies have shown that pomegranate can reduce measures of oxidative stress. In one study, administration of Pomegranate juice to diabetics for 6 weeks reduced oxidized LDL levels. Another study documented its ability to lower lipid peroxides which contributes to the worsening of circulatory problems.
Inflammation A study of diabetic patients showed that the levels of the inflammatory markers Hs-CRP and IL-6 were lowered by 30% after 4 weeks of pomegranate juice intake.85
Lipid Lowering Effects Juice containing pomegranate and other antioxidant fruits was given to 44 subjects for 4 weeks resulting in a lowering of total cholesterol and LDL levels as well as increasing the “good” cholesterol -HDL.
High Blood Pressure 6 weeks of drinking pomegranate juice resulted in decreased systolic and diastolic blood pressure in Type 2 diabetics [99].In traditional Persian medicine Pomegranate juice, whole fruit, seed extract, and seed oil, have all been used in as anti-hypertensive, cardioprotective , and lipid lowering agents [117].
Lowering of Serum Cortisol One hour after drinking pomegranate juice, a lowering of the stress hormone cortisol was shown in a study of eight nine diabetic subjects.[103].E
Obesity Pomegranate ingestion by fifty study subjects for eight weeks lowered insulin resistance, HsCRP, and body weight.
Cancer Pomegranate exhibits anti-cancer activity inhibiting the proliferation of tumor cells [106].
Oral Cavity – Dental Plaque Gingivitis and Periodontitis A significant reduction in the signs of chronic periodontitis and IL-1 levels were shown after pomegranate ingestion [172].
Dementia A new study from the University of Copenhagen concluded that a substance present in pomegranates may improve memory and possibly help in the treatment of Alzheimer’s disease
ASHWAGANDA
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Ashwagandha is a true regenerative tonic due. It has been used for Parkinson’s Disease, memory loss, and dementia. It has also been applied as a therapy for strokes causing paralysis and neuronal deficits, which have improved with long term treatment.
Stress and anxiety
Many clinical research have confirmed that ashwagandha extracts help reduce stress and anxiety. It may improve cardiovascular health through its effect on lowering elevated cortisol levels and modulating stress induced blood pressure elevation. A systematic review of seven such was published in 2021 [7]. There were a total of 491 adult subjects who suffered from high stress and anxiety. They were given either ashwagandha or placebo for 6 to 8 weeks. These studies found that ashwagandha significantly reduced stress and anxiety levels (measured by validated anxiety rating scales), and improved their sleeplessness and fatigue.
Ashwagandha has been shown to work as an analgesic .(Twajj et al., 1989), effective for the pain of arthritis (Singh et al. 1984, 1986). Ashwagandha has been shown to exhibit multiple pharmacological actions that are antitumor, anti-arthritic, analgesic and anti-inflammatory. It is also used as an adjunctive modality in a number of different forms of cancer. Large scale clinical studies are needed to further advance our knowledge of this potentially valuable therapeutic tool in stress related disorders, nervous system conditions and cancer
Sleep
Clinical trials that have been done suggest that ashwagandha may help with sleep. At one study center in India, 150 healthy adults between 18 to 65 years of age with self-reported insomnia were randomized to take an ashwagandha or placebo for 6 weeks [12]. Improvements in sleep quality were significant in the ashwagandha group (72%) compared with the placebo group (29%). The participants taking ashwagandha showed improvements in time in bed spent in sleep, and sleep latency (time elapsed to fall asleep). They also reported improvements in quality of life.