Tirzepatide: A Breakthrough in Weight Loss


Tirzepatide (Mounjaro) ia a once weekly GIP (glocose-dependent insulinoptropic polypeptide0 receptor and GLP-1 (glucagon-like peptide-1) receptor agonist. Tirzepatide activates the body’s receptors for GIP and GLP-1, which are found in the brain in the areas that control appetite regulation. Thus, as a result,  tirzepatide reduces food intake shown in multiple studies. It also impacts fat utilization and as such has a mechanism which enhances fat loss for those who utilize tirzepatiode in their weight loss programs. Along with its effectiveness for weight loss, tirzepatide is being studied for its possible therapeutic benefit in sleep apnea as well as fatty liver, heart disease and chronic kidney disease.
Tirzepatide (Mounjaro) was originally approved by theFDAfor its use in diabetic patients for its actions and blood sugar control. However because of its success, and the mechanism by which it works it has been shown to be extremely effective in weight loss programs, which logically can help a host of other medical conditions. Therefore it is being prescribed by many doctors  for its “off label” use in weight loss and its associated conditions.
In a major study published in Nature Medicine tirzepatide was taken for 72 weeks and the weight loss reported can be seen as astounding. The patients were weighed at an average of 241lbs and lost 64.4 pounds by the end of the study period. In order to accompish this result the use of tirzepatide was accompanied by intensive lifestyle intervention that included a low calorie diet, exercise and counseling sessions. Researches who a manged the study released the following statement, ” people who added to tirzepatide to diet and exercise saw greater, longer-lasting weight reduction than those taking a placebo”.

Side effects can occur with Tirzepatide as with all medications, but they are generally mild to moderate in severity. They include nausea, diarrhea or constipation. Vomiting may occur but is much less frequent. These are the only common side effects, while others occur rarely. As with many medications, side effects are related to the dosage that is used. As  a result patents are advised to start with a relatively low dose of 2.5 mg. Common practice is to increase the dose every weeks 4 weeks as tolerated. The higher dose is expected to be more effective for appetite control, and  thus patients generally increase their dose to 10mg  as long they are not limited by side effects. The maximum dose is 15mg .

Regarding the use of medication to achieve weight loss it has to be recognized that it is difficult for most people to make the necessary changes based on their determination and willpower. Therefore as stated by the spokesperson for Eli Lilly who produces the medication, “while intensive lifestyle intervention is an important part of ob esity management, these results underscore the difficulty some people face maintaining weight loss with diet and exercise alone.”

Monjauro’s success has been a game changer for so many people, and its popularity seems to keep increasing. One reason for it becoming so well known is that many prominent public figures in show business and industry have been open about the fact that they have used it for their own weight loss efforts.  It seems to have gotten to the point that when a prominent person loses weight they are suspected of having used this type of medication and are asked about it.

A similar medication originally developed for diabetes which doctors and their patients are using for weight control is called Ozempic, (GLP-1 agonist Semaglutide) . In addition to all of the ways in which people have become aware of both Mounjaro and Ozempic there is an even greater awareness of them related to the popularity of the variety of social media sites through which word of their effectiveness continues to spread.

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