Sermorelin – Enhancing Growth Hormone Production Naturally

Growth hormone secretagogues (GHS) such as sermorelin  have emerged as therapy to reverse the signs and symptoms of aging.

Sermorelin Health Benefits

  • Anti-aging- aesthetic effects
  • Libido and sexual health
  • Muscle strength and energy
  • Lowers body fat 
  • Reduces risk of osteoporosis 
  • Cardiovascular benefits 

Growth Hormone and IGF-1 stimulators can significantly improve body composition by reversing aging effects such as fat gain and muscular atrophy. Sermorelin is a GHRH (growth hormone releasing hormone) peptide derived from the first 29 amino acids of the GHRH protein (23). 

Growth Hormone  therapy has been shown to improve lean body mass, decrease body fat , and improve serum lipid profiles (16,17). One published meta analysis which included 54 scientific studies published in 2012 found that  patients who received Growth Hormone therapy had a significant reduction in body fat measurements accompanied by increased muscle mass(18). 

As a result of the practical limitations to the use of growth hormone, GH secretagogues emerged as an alternative. These agents  appeared  to impart many of the same beneficial effects as seen with Growth hormone  therapy itself. Growth hormone secretagogues are made of amino acid chains called peptides which can enhance a person’s natural hormone production, and thereby mimic the benefits of growth hormone therapy without the use of growth hormone itself.

The researcher  Dr. Khorram and his colleagues conducted a single-blind randomized placebo-controlled trial to evaluate the effects of sermorelin in both elderly men and women over an extended treatment duration of 5 months (). Ten women and nine men between 55 and 70 years old were administered 4 weeks of nightly subcutaneous placebo followed by 16 weeks sermorelin injections.  The study showed that sermorelin led to increased  Growth Hormone release for the 2 hours after its injection and elevated the 12-hour  mean Growth hormone levels measured at both 4 weeks and 16 weeks for both genders.

Research which appeared in the Journal of clinical Endocrinology and Metabolism in 1992 by E Corpas and his team published an evaluation of sermorelin’s effects on GH and IGF-1 levels in 9 young men 22 to 33 years old and 10 elderly men from 60 78 years old (27). The study subjects were  ten elderly men who were given 14 days of  injections . These older men had lower baseline IGF-1 levels when compared to the younger men, and sermorelin treatment resulted in elevations in IGF-1 related to the dose administered, achieving levels approaching those of the younger men. It was also seen that the measured elevations of IGF-1 (Growth hormone) remained above baseline levels in the elderly men even 2 weeks after stopping sermorelin, providing evidence that sermorelin can produce long lasting effects. 

Compared to their baseline, the mean peak GH secretory responses were significantly increased in elderly men at both low and high doses. The authors also observed that the areas under GH peaks at night were significantly higher than those during the day for both young and elderly men, confirming that the majority of GH release occurs at night irrespective of age. These findings highlight that sermorelin is an effective stimulator of GH and IGF-1 levels in elderly men with reduced IGF-1 levels.

Another small study conducted enrolled 11 healthy older men between the ages of 64 and 76 years old. They received nightly injections for 6 weeks (28).  Assessments were done at the end of the six week study period  and included metabolic testing, body composition, GH, and IGF-1 levels, and also assessment of muscle strength and function. The Sermorelin therapy was shown to nearly double the 12-h mean amount of GH released by the pituitary, but blood testing showed that the levels did not go above physiological norms. Sermorelin treatment successfully lead to significant improvements in muscle strength tests, muscle endurance and the abdominal crunch test.  The treatment did not result in any change in testosterone levels measured. It was also noted that a decrease in mean systolic blood pressure was observed.

Sermorelin is self administered using a subcutaneous (under the skin) injection with minimal discomfort.

Semorelin has  a very good safety profile.  Infrequent side effects include redness at the injection site, and facial flushing, and nausea rarely.

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