KPV is a naturally occurring tripeptide composed of the amino acids  Lysine, Proline and Valine. It has been extensively researched and found to be non-toxic and very well tolerated.

KPV is a well researched peptide used for overall gut health and has shown effectiveness for the treatment of inflammatory bowel disease (IBD). Its anti-inflammatory properties make KPV also helpful with skin conditions such as psoriasis.

It has been shown to be effective for Inflammatory Bowel Disease Crohn’s Disease and Ulcerative Colitis by reducing the inflammatory responses of colonic cells, with KPV acting inside of the cell. The current standard treatment for ulcerative colitis is the use of immunosuppressive drugs to control the inflammation of the gastrointestinal tract. Unfortunately these drugs are  associated with serious  adverse side effects including the promotion of osteoporosis and an increased susceptibility to infection.5, 6   There is a great need for non-toxic treatments for this condition. Thus, KPV may be an important and safe alternative.

Ulcerative colitis is a chronic, relapsing inflammatory disease of the colon. 1 The inflammatory response of the lining of the colon damages the colonic mucosal barrier, which causes increased permeability of epithelial barrier increasing the risk of bacterial invasion of the colonic tissues. An excessive immune reaction is believed to underly the symptoms of ulcerative colitis- diarrhea accompanied by bloody stools. 2  The goal in treatment for ulcerative colitis is to promote mucosal healing and alleviate inflammation and its consequences .3, 4    Studies have shown that KPV can lessen the inflammatory response of the colon- the  epithelial lining and immune cells. This can hopefully prevent instances of the ulcerative colitis flareups.11, 12  KPV exerts its anti-inflammatory function inside of the colonic cells, inactivating the overactive inflammatory metabolic pathways.12  The mechanism by which KVP acts as an anti-inflammatory treatment is to inhibit the activation of NF-kappaB and MAP kinase inflammatory  pathways  reducing the secretion of pro-inflammatory cytokines. KPV is not associated with any significant side effects.  

https://pubmed.ncbi.nlm.nih.gov/18061177/

httpsps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498804/

Together, these results show that KPV reduces NF-κB and MAPK activation which constitute the classical signaling pathways involved in cytokine secretion by inflamed IEC.

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease.

The fact that KPV acts locally after oral ingestion makes it a n excellent candidate for effective treatment.

https://pubmed.ncbi.nlm.nih.gov/23036075/

Since IBD (Inflammatory Bowel Disease) is chronic and relapsing, patients are generally placed on a regimen of lifelong medication. The immunosuppressive agents used to treat the condition have significant adverse effects. Oral colon-specific agents are used to deliver the therapeutic effect locally and target pathophysiological inflammatory manifestations of Inflammatory Bowel Disease. KPV can be taken orally and be active in the colon after it is ingested. It has not been associated with any significant negative side effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431115/

MAXIMIZING THERAPY USING KPV TOGETHER WITH BPC -157  

Body Protective Compound, known as BPC-157 is a fifteen amino acid peptide originally derived from gastric juice secretions. It has been used in a variety of inflammatory conditions for many years. https://drsobo.com/peptides/bpc–157/

BPC-157 treats a number of the most common gastrointestinal problems.  It can be given as an orally because it is stable in gastric juice after ingestion. It benefits stem from helping optimal functioning of the gut-brain axis-the connection between the gastrointestinal tract, and the nervous system.

BPC-157 is used to treat

• Irritable Bowel Syndrome
• Leaky gut syndrome
• Ulcers  
• Crohn’s disease
• Ulcerative colitis
• Chronic Constipation or diarrhea

Both KPV and BPC-157 can be given together to enhance the therapeutic effect for a more complete healing treatment to combat IBD (Inflammatory Bowel Disease.

Ulcerative Colitis and Crohn’s Disease are the two conditions encompassed by the term IBD-Inflammatory Bowel Disease. Safe, non toxic treatments need  to be further studied and developed.