Peptide MK-677

MK-677 (Ibutamoren) promotes the secretion of the growth hormone by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Clinical studies describe only the effects ibutamoren has on appetite and as expected, like ghrelin, appetite is increased.. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition.

Benefits of MK-677:

Helps Build Muscle MK-677 is frequently used as an anabolic substance, to increase lean body mass. It is orally active and can be taken once a day. MK-677 stimulates Growth Hormone and IGF-1 which each

When it comes to MK-677 stimulating muscle growth, its results will vary by person depending on their exercise regimen and if they have any health conditions.

In another study of 24 obese men, a two-month treatment with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR)

Reduces Muscle Wasting: MK-677 has shown in recent studies to alleviate muscle wasting that can be caused by a decline in protein within an individual’s diet.

Increases Bone Density: Several studies have indicated that long-term use of MK-677 can have tremendous results to increase bone mineral density. This finding can benefit several populations including obese individuals, older adults, and women with menopause.

In 24 healthy obese male volunteers, ibutamoren increased bone turnover.

In 187 elderly adults (65 years or older), ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover in multiple studies.

In one study with 292 post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis.

Improves Sleep: Since Growth Hormone is known to help improve sleep quality, it is commonly thought that Ibutamoren Mesylate can assist with sleep quality since it stimulates production in Growth Hormone.

A study showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration.

Combats Aging and May Increase Longevity: As seen with other hormones in the body, Growth Hormone naturally begins a steady decline once a certain age is hit. Individuals who are aging can benefit from taking MK 677 since Growth Hormone and IGF-1 will be increased in the body among its consumption. Aging individuals who take MK 677 can improve their overall hormone profiles as they give their declining GH levels (Growth Hormone levels) a boost.

May Have Nootropic Effects:

Obtaining the proper amount of sleep each night is extremely important when trying to achieve adequate cognitive function. MK-677 can improve cognitive function by assisting individuals with the ability to get a good night’s rest. The ability of MK-677 to stimulate IGF-1 production can also indirectly improve cognitive function based on IGF-1’s role in cognitive function. One study indicated that IGF-1 positively affected participants’ ability to perform well on cognitive tests.

Side effects:

Overall, MK 677 has not produced very many side effects for its users to be concerned about, but certain populations may have certain side effects to look out for. Individuals who are vulnerable to insulin sensitivity or who have Diabetes may be at risk when taking MK-677. Symptoms associated with these conditions could possibly be exacerbated by the use of MK 677. As with any other compound, correct dosing and usage of MK-677 is the key. In studies that looked at how MK-677 increases muscle mass, the dosage was key. Side effects of MK-677 are usually the result of a handful of two things: improper dosage and extended use.

Conclusion:

MK 677 has shown through numerous studies to benefit the elderly, those with obesity, have problems sleeping, have low bone density, and others. For these populations, MK 677 can be used as a helpful tool to combat issues that can be caused in large part due to a lack of Growth Hormone and IGF-1.

Research/References:

J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Murphy MG1, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR
J Clin Endocrinol Metab. 1996 Dec;81(12):4249-57. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. Chapman IM1, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO.
Neuroendocrinology. 1997 Oct;66(4):278-86. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Copinschi G1, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E.