Long before vitamin C was seen as just a cold remedy, Dr. Fred Klenner — an early 20th-century physician and medical pioneer — used it to treat some of the most severe medical conditions of his time. In his 1959 book “The Key to Good Health, Vitamin C” Klenner laid out decades of clinical case studies showing dramatic recoveries using intravenous (IV) vitamin C, often in cases where standard treatments had failed.
“The Master Key to Perfect Metabolism”
Dr. Klenner didn’t mince words. He opened his book with a bold statement:
“The Master Key to Perfect Metabolism is the detoxifying effect of Vitamin C on all contaminants in your blood.”
He believed that vitamin C wasn’t just a supplement — it was foundational to health. Working throughout the 1940s and 1950s, Klenner used high doses of vitamin C to address viral, bacterial, inflammatory, and even toxic conditions.
He wasn’t alone. Nobel laureate Linus Pauling also became a vocal supporter, taking 3,000 mg of vitamin C daily for decades until his death at nearly 94. Another voice was Dr. J.U. Schlegel of Tulane University, who recommended 1,500 mg per day to prevent bladder cancer recurrence — based on five years of clinical evidence.
How Vitamin C Works in the Body
Klenner explained that vitamin C plays a central role in building and maintaining connective tissue, like collagen, blood vessel walls, cartilage, bone, and skin. Without it, wounds will not heal, fractures will not mend, and children cannot grow properly. It’s especially crucial in aging, where tissue regeneration slows. Vitamin C also supports adrenal function. These glands produce cortisol, a critical hormone for stress response and inflammation control. According to Klenner, without enough vitamin C, adrenal function is compromised.
Treating Viral Infections with IV Vitamin C
Dr. Klenner’s most dramatic cases often involved viral infections where antibiotics don’t help. Here are a few examples from his reports:
- Polio: Klenner documented fourteen cases of polio cured with IV vitamin C. In most cases, patients were discharged within a week, fully recovered. These results were echoed by Dr. Granville Knight, who used Klenner’s protocol and later led the Price-Pottenger Foundation.
- Shingles (Herpes Zoster): Patients were given 2–3 grams of IV vitamin C every 12 hours. Seven out of eight experienced pain relief within two hours, and lesions cleared within 72 hours without painkillers.
- Viral Encephalitis: One patient with a 106.8°F fever, severe pneumonia, and near-unconsciousness showed rapid improvement after IV Vitamin C therapy, eventually making a full recovery. This included reversal of hearing loss as well.
- Influenza, Herpes, and Mononucleosis: Though not detailed in case reports, Klenner and later researchers (like Dr. Thomas Levy) found high-dose vitamin C to be effective across a wide spectrum of viral illnesses.

Fighting Bacterial Infections with Vitamin C
While not an antibiotic, vitamin C appears to boost the immune system in a way that enhances the body’s ability to fight bacterial infections:
- Rheumatic Fever: In a 1955 Archives of Pediatrics study, Klenner treated patients with daily IV vitamin C and observed no progression to the serious heart condition known as rheumatic heart disease.
- Whooping Cough (Pertussis): In a 1950 JAMA report, 90 children were treated with 500 mg of vitamin C IV per day. Most recovered fully in 15 days. This is a significant improvement in recovery time.
Detoxification: Vitamin C and Lead Poisoning
Klenner described how vitamin C could bind with lead in the bloodstream, forming an insoluble compound that’s then eliminated by the liver. This chelation-like effect made vitamin C an early option for treating heavy metal toxicity, decades before chelation therapy became mainstream.
Skin and Allergy Relief
In cases of atopic dermatitis, urticaria, poison ivy, and other skin conditions, IV vitamin C brought rapid relief. According to a 1953 Annals of Allergy report, itching often stopped after initial treatment, and lesions began to heal quickly thereafter.
Emergency Medicine: Burns, Alcoholism, and Anemia
Vitamin C also proved useful in acute medical emergencies:
- Severe Burns: A case reported in the US Armed Forces Medical Journal (1951) involved a patient with burns over 90% of the body. IV vitamin C combined with B-complex vitamins was key in the patient’s survival and recovery.
- Delirium Tremens (Alcohol Withdrawal): In BMJ and JAMA reports from the 1950s, IV vitamin C, B1, and B6 helped rapidly calm symptoms in alcohol withdrawal patients.
- Iron Absorption and Anemia: A 1954 study in The Journal of Pediatrics showed that vitamin C significantly improves iron absorption when taken orally—important in treating iron-deficiency anemia.
Cancer and High-Dose Vitamin C
Dr. Klenner’s doses (usually 1,000–3,000 mg IV) laid the foundation for what is now called High-Dose IV Vitamin C Therapy, especially in cancer care. Later protocols pushed the dose much higher — sometimes 25,000 mg or more.
Today, research is catching up. A recent study from the University of Iowa found that adding high-dose IV vitamin C to chemotherapy doubled survival time in advanced pancreatic cancer patients. This is now gaining renewed interest as an integrative cancer treatment.
Read more: University of Iowa Study
Best IV Vitamin C Therapy in Connecticut
Dr. Klenner’s work was far ahead of its time. Though many of the diseases he treated, like polio or severe rheumatic fever, are now rare, the principle remains: Vitamin C is more than a supplement. In high doses, it can act like a therapeutic tool. Modern research is starting to validate what Klenner demonstrated decades ago. As more clinicians revisit his protocols, we may see vitamin C reclaim its place in modern medicine. If you want to opt for IV Vitamin C in Connecticut, you can book an appointment with Dr. Sobo. Call 203-348-8805.