Glutathione- essential molecule and master detoxifier 

 Glutathione is found in every cell of the human body. It is a tripeptide, composed of three essential amino acids

 (cysteine, glutamate, and glycine), and is considered the master natural detoxifier.

 It plays a crucial role in reducing oxidative stress, enhancing metabolic detoxification, and

 regulating the immune system. Many age-related chronic disease states such as those related to

neurodegeneration, mitochondrial dysfunction, and cancer, seem to be associated with deficient or suboptimal levels.

Research is provided an increasing awareness of Gltuthione’s utility in mitigating body toxin load through its ability to

Glutathione enhances the liver’s ability to convert and excrete toxic compounds such as mercury and a host of pollutants we are exposed to in our modern environments. It confers some protection for the liver against alcohol and other organic pollutants.

 

Glutathione’s functions in the body

  1. Neutralization of free radicals
  2. A cofactor for antioxidant enzymes
  3. Regeneration of vitamin C and vitamin E
  4. Phase I liver metabolism of chemical toxins
  5. Phase II liver reactions, making toxins water soluble for excretion by the kidneys
  6. Elimination of mercury from body tissues
  7. Essential to mitochondrial functions and maintenance of mitochondrial DNA
    • Glutathione is helpful for:
    • Enhancement of proper immune functioning.
    • Reducing inflammation
    • Improves energy
    • Improved concentration and focus.
    • Better sleep.
    • Detoxification of toxic substances from the body.
    • Slowing the signs of aging.
  • Clinical conditions and diseases associated with glutathione.

  • Since research has shown that many chronic diseases are associated with  reduced glutathione levels it is hoped that  improving  glutathione levels may  help many clinical disorders.  Therefore improving glutathione levels via a number of therapies has been applied by clinicians to help:
    • chronic liver disease
    • cognitive impairment
       diabetes
    • hypertension
    • infertility in both men and women
    • autoimmune conditions- lupus
    • multiple sclerosis
    • neurodegenerative disorders
    • Parkinson’s disease

    • aging  and related disorders
    • Alzheimer’s disease
    • cancer prevention

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770193/

    CAN YOU ENHANCE GLUTATHIONE LEVELS WITH DIET ?

    Eating foods rich in the precursors of glutathione may be helpful. These are the  foods rich in sulfur containing amino acids such as lean meats, poultry, fish, eggs, legumes, nuts, and seeds. Clinical experience however seems to show that people need a more direct to treatment to enhance their glutathione levels.

  • CAN YOU TAKE GLUTATHIONE SUPPLEMENTS ?  How effective taking glutathione is as a supplement is controversial. Rather than direct supplementation with glutathione, 
  • It may be beneficial to utilize milk thistle, N-acetyl cysteine, Vitamin E and selenium.
  • A small studyTrusted Source indicated that whey protein,  given orally, improved psoriasis . Whey protein has been shown to increase glutathione levels. Study subjects were given 20 grams as daily for three months.
  • WHY WHAT ABOUT INTRAVENOUS GLUTATHIONE TREATMENTS ?

     

    Intravenous treatment provides an immediate elevation of glutathione levels in the body whereas oral supplements take much longer and may and may be much less effective.

  • Glutathione benefits

    Reduces oxidative stress

    Oxidative stress occurs when there’s an imbalance between the production of free radicals and the body’s ability to fight them off. Too-high levels of oxidative stress may be a precursor to multiple diseases. These include diabetes, cancer, and rheumatoid arthritis. Glutathione helps stave off the impact of oxidative stress, which may, in turn, reduce disease.

    An article cited in Journal of Cancer Science and Therapy indicated that glutathione deficiency leads to increased levels of oxidative stress, which might lead to cancer. It also stated that elevated glutathione levels raised antioxidant levels and resistance to oxidative stress in cancer cells.

    Reduces cell damage in alcoholic and nonalcoholic fatty liver disease

    Cell death in the liver may be exacerbated by a deficiency in antioxidants, including glutathione. This can lead to fatty liver disease in both those who misuse alcohol and those who don’t. Glutathione has been shown to improve alcoholic and nonalcoholic chronic fatty liver disease.

    studyTrusted Source reported that glutathione was most effective when given to people with fatty liver disease intravenously, in high doses. Participants in the study showed reductions in malondialdehyde, a well known marker of cell damage in the liver.

    Another small studyTrusted Source found that orally administered glutathione had positive effects on people with nonalcoholic fatty liver disease following proactive lifestyle changes. In this study, glutathione was provided in supplement form in a dose of 300 milligrams per day for four months.

    Improves insulin resistance in older individuals

    As people age, they produce less glutathione. Researchers at Baylor School of Medicine used a combination of animal and human studies to explore the role of glutathione in weight management and insulin resistance in older individuals. Study findings indicated that low glutathione levels were associated with less fat burning and higher rates of fat storing in the body.

    Older subjects had cysteine and glycine added to their diets to increase glutathione levels, which spiked within two weeks, improving insulin resistance and fat burning.

    Increases mobility for people with peripheral artery disease

    Peripheral artery disease occurs when the peripheral arteries become clogged by plaque. It most commonlyTrusted Source happens in the legs. One study reported that glutathione improved circulation, increasing the ability of study participants to walk pain-free for longer distances. Participants receiving glutathione rather than a saline solution placebo were given intravenous infusions two times daily for five days, and then analyzed for mobility.

    Reduces symptoms of Parkinson’s disease

    Parkinson’s disease affects the central nervous system and is defined by symptoms such as tremors. It currently has no cure. One older study documented intravenous glutathione’s positive effects on symptoms such as tremors and rigidity. While more research is needed, this case report suggests that glutathione may help reduce symptoms, improving quality of life in people with this disease.

    The chronic inflammation caused by autoimmune diseases can increase oxidative stress. These diseases include rheumatoid arthritis, celiac disease, and lupus. According to one studyTrusted Source, glutathione helps reduce oxidative stress by either stimulating or reducing the body’s immunological response. Autoimmune diseases attack the mitochondria in specific cells. Glutathione works to protect cell mitochondria by eliminating free radicals.

      May reduce the impact of uncontrolled diabetes

    Long-term high blood sugar is associated with reduced amounts of glutathione. This can lead to oxidative stress and tissue damage. A study found that dietary supplementation with cysteine and glycine boosted glutathione levels. It also lowered oxidative stress and damage.

     May reduce respiratory disease symptoms

    N-acetylcysteine is a medication used to treat conditions such as asthma and cystic fibrosis. As an inhalant, it helps to thin mucus and make it less paste-like. It also reduces inflammation. N-acetylcysteine is byproduct of glutathioneTrusted Source.

    Glutathione is found in some foods, however cooking and pasteurization diminishes it significantly.

    • In nature glutathione is most abundant in
    • freshly-picked fruits and vegetables, especially asparagus and avocado.
    • very rare meat
    • unpasteurized dairy products
  • WHAT ARE THE CONDITIONS FOR WHICH GLUTATHIONE INFUSIONS MAY BE HELPFUL?

    • Chronic Fatigue / Fibromyalgia
    • Liver problems
    • Autoimmune and other immune related conditions
    • Toxic Metal and Chemical Toxicities
    • Neuropathy
    • Depression-mood disorders
    • Athletic/ Muscle / Energy Enhancement
    • Generalized Aging
    • Generalized disease prevention
    • Inflammatory Bowel
    • For reducing hyperpigmentation of the skin
    • Insulin Resistance A 2018 study Trusted Source study showed that people with insulin resistance tend to have lower glutathione levels. This was especially true of those who had neuropathy or retinopathy.
    •  According research Trusted Source, there is evidence that maintaining glutathione levels may help with the symptoms of Parkinson’s disease and Parkinson-like tremor.
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