Excess Weight , Inflammatory Proteins and Colon Cancer Risk

 A new study from Tufts University published in the scientific journal Cancer Epidemiology, Biomarkers & Prevention ads to the evidence that obesity promotes cancer through inflammation. Two inflammatory proteins in the colon increase with increasing weight. Two pre-cancerous cellular pathways are activated by these inflammatory proteins.

Lead researcher  Joel B. Mason, M.D., a gastroenterologist who studies nutrition and cancer prevention states, “Our results establish, for the first time, that concentrations in the colon of two major cytokines increase in concert with increasing BMI in humans. The increased concentrations are accompanied by changes in gene activation within the lining of the colon that are pro-cancerous in nature.”

Cytokines are proteins that mediate and regulate immunity and inflammation, among other things. In addition to evidence that they can promote cancer risk in certain tissues. Using blood samples and colonic biopsies, the researchers determined that the concentrations of two major cytokines rise as the level  of excessive body weight increases.

The authors of the study say, “the results cannot prove that the observed changes in the colonic transcriptome are due to the rise in cytokines. Observations from this study nevertheless underscore the potential contribution that the establishment of an inflammatory milieu in the colonic mucosa may play in explaining the enhanced risk of colon cancer due to obesity.”

Colorectal cancer is the third most common cancer in the US  and is the second leading cause of death due to cancer. For your individualized weight loss plan contact Dr Sobo.https://drsobo.com/therapeutic-services/weight-loss/

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