All posts in Regenerative Medicine

Dr Sobo’s Blog Wins Recognition Award from the Alzheimer Society

Dr Sobo’s Blog Wins Recognition Award from the Alzheimer Society

I am proud to be named as one of the top Dementia blogs, congratulated by the Alzheimer’s Society. Please see all of the great information available by a variety of writers.Feedspot Blog Reader

Top 60 Dementia Blogs And Websites For People Living With Dementia
http://blog.feedspot.com/dementia_blogs/

Congratulations Winners!!

Doctor Henry Sobo, MD

 

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

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Platelet-Rich Plasma Injections Improve Tissue Healing

Platelet-Rich Plasma Injections Improve Tissue Healing

A study from the University of Alberta Sports Medicine Clinic has shown that  PRP (platelet-rich plasma) injections given to patients  with chronic shoulder pain, not only improved pain and function, but enhanced the healing process in the tissues.  This was the first study to document the enhancement of tissue healing, using before and after MRI studies of the shoulder.

Dr. Doug Gross one of the studies authors says,”Based on MRI findings before and after the injections, we saw improvements in the tissue six months later in five of seven patients undergoing PRP and an appropriate rehabilitation program. The healing in the tissue appeared to correspond with the reported improvement of the pain and also with the clinical assessment of function”

Lead author of the study Marni Wesner, sports medicine physician explained their procedure; “We studied patients 35 to 60 years old with rotator cuff tendinopathy due to normal aging. For the first time, we were able to not only find reported improvements in pain and mobility, but also in the tissue — the MRI before and after showed structural change and a decrease in the size of tears.”

Platelet-rich plasma injection  is an increasingly popular  therapeutic procedure  for the treatment of both acute and chronic  injuries. It involves collecting blood from the patient’s arm, separating the platelets via centrifuge and injecting it back into the patient’s injured tissue area to augment the body’s natural healing response. Treatment with Platelet Rich Plasma has received increased attention after it became known that sports starts like Tiger Woods, Kobe Bryant and Alex -Rodriguez  have been treated with it.

One study subject 58 year old retired police offers Debbie Brown describes her results as life changing “For the past two years, I have tried everything for my right shoulder. Physio would help for a bit but then the problem would still be there. I tried acupuncture, Kinesio tape, cortisol injections — you name it, I’ve tried it,” she said. “Once I did the PRP, it really did fix everything!  I can work out and be active again.PRP makes me feel like I’m in my 20s!”.

For more about PRP treatment at Dr. Sobo’s office see prp http://drsobo.com/dr-sobos-prp-platelet-rich-plasma-program/

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

 

 

 

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PRP (Platelet Rich Plasma) Effective Treatment for Knee Osteoarthritis Study Shows

PRP (Platelet Rich Plasma) Effective Treatment for Knee Osteoarthritis Study Shows
A study from the Hospital for Special Surgery published in the Clinical Journal of Sports Medicine shows that platelet-rich plasma (PRP) holds great promise for treating patients with knee osteoarthritis. The treatment consistently improved pain and function, and in nearly ¾ of the study participants appeared to delay the progression of osteoarthritis which is a progressive disease.

“This is a very positive study,” said Brian Halpern, M.D., lead author of the study and chief of Sports Medicine Service at the Hospital for Special Surgery in New York City.

PRP (Platelet Rich Plasma) is a  new treatment that is being used by a small but growing  number of doctors. PRP, which is  produced from a patient’s own blood is given back into the body as an injection, delivering a high concentration of growth factors to an arthritic joint to stimulate the healing process. Dr Halpern explains the simple procedure this way- “You take a person’s blood, you spin it down, you concentrate the platelets, and you inject a person’s knee with their own platelets in a concentrated form. This then activates growth factors and stem cells to help repair the tissue, if possible, calm osteoarthritic symptoms and decrease inflammation.”

In the study, researchers enrolled patients with early osteoarthritis, gave them each an injection of PRP , and then monitored them for one year. They used validated measures to assess overall knee pain, stiffness and function, as well as a patient’s ability to perform various activities of daily living. At baseline and then one year after the PRP injection, physicians also evaluated the knee cartilage with magnetic resonance imaging (MRI).

It is generally accepted  that patients with osteoarthritis lose roughly five percent of knee cartilage per year, the Hospital for Special Surgery investigators found that a large majority of patients in their study had no further cartilage loss after one year.

Treatment with PRP was also useful in improving pain, stiffness and function with a reduction of between 42 % nearly 60 % at six months and one year. Activity of Daily Living Scores also showed a significant increase at both six months (47%) and one year (56%).

Dr. Halpern said, “We are entering into an era of biologic treatment…, where you can use your own cells to try to help repair your other cells, rather than using a substance that is artificial. The downside is next to zero and the upside is huge.”

Osteoarthritis impacts nearly 30 million Americans and is a leading cause of disability. It affects a third of those older than 65. The disease is characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth.

For more about PRP treatment see prp http://drsobo.com/dr-sobos-prp-platelet-rich-plasma-program/

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

 

 

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Adult Stem Cell Treatment Reverses Multiple Sclerosis in Trial

Reporting results  from an FDA-approved clinical trial involving researchers in the U.S., U.K., Sweden and Brazil in the journal  Stem Cell Autoimmune Neurology , treatment of  multiple sclerosis with adult stem cells therapy produced “remarkable” results. This clinical phase 3 trial started in 2006  adding patients and observing results ever since then. The doctors treating  these patients with adult stem cell therapy, recorded detailed examinations of their progress,validating their observations.

The stem cell therapy procedure used  was developed by Dr. Richard Burt of Northwestern University Feinberg School of Medicine. In 2015, the international group reported some of their own initial results with relapsing­-remitting MS subjects that were very encouraging. The adult stem cells which were administered not only stopped disease progression, but for many of the patients actually reversed and improved the patients’ neurological disabilities.  Do date there is no FDA-­approved therapy which has reversed MS symptoms or improved the quality of life for these patients. Dr. Burt states  that this is the only therapy to date that has shown to reverse neurologic deficits in relapsing-­remitting MS.

Of particular note was the case of Steven Storey, a marathon runner who developed MS and  became wheelchair­-bound and was virtually paralyzed. After four months of the treatment he reported that he could stand, and in less than ten months he was walking again and also completed a mile-­long swim.

Another patient, Holly Drewry, had also become wheelchair-bound from her MS. She began to notice changes in her strength just days after her treatment, and she soon walked out of the hospital.

For more information on Stem Cell Therapy please see

Stem Cell Therapy and Regenerative Medicine

 

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Stem Cell Treatment Improves Dementia an Motor Impairments of Lewy Body Disease, Study Says

Stem Cell Treatment Improves Dementia an Motor Impairments of Lewy Body Disease, Study Says

Neural stem cells transplanted into areas of brain damage in mice dramatically improved both motor and cognitive impairments associated with  Lewy Body Dementia, according to a study from the University of California Irvine Institute for Memory Impairments and Neurological Disorders. Their  findings were published in the journal Stem Cell Reports in October 2015

Lewy body Dementia is the second-most common type of age-related dementia after Alzheimer’s disease and is characterized by the accumulation of a protein called alpha-synuclein that collects into masses called Lewy bodies. Lewy bodies are also known to accumulate in other neurologic disorders such as Parkinson’s disease. This pathology impairs the normal function of neurons, leading to alterations in critical brain chemicals and neuronal communication and eventually, to cell death.

In this study mouse neural stem cells were transplanted into genetically modified mice having many of the signs and symptoms  of Lew Body Dementia. One month later, the mice were retested on a variety of behavioral tasks, and significant gains in both motor and cognitive function were observed. For example, these mice could run on a rotating rod for much longer and recognize novel objects far better than untreated mice.

The study examined the effects of the stem cells on brain cell dysfunction. They found that the improvements seen required the production of a specific growth factor  called brain-derived neurotrophic factor (BDNF) by neural stem cells.

The team examined two of the key brain structures that become dysfunctional in Lew Body Dementia , dopamine and glutamate making neurons. Lead researcher Natalie Goldberg explained, “Our experiments revealed that neural stem cells can enhance the function of both dopamine and glutamate producing neurons, coaxing the brain cells to connect and communicate more appropriately. This, in turn, facilitates the recovery of both motor and cognitive function.”

Testing the possibility that BDNF alone might be an effective treatment, they studied the effect of delivering  the growth factor directly into to the brains of Lewy Body Dementia mice.

it was found that this treatment resulted in good recovery of motor skills in the test rodents but only limited recovery of cognitive function. This, researcher Goldberg said, suggests that while BDNF is critical to stem cell-mediated motor and cognitive recovery, it does not achieve this outcome alone. It appears that other changes initiated by stem cells are also at play in the mechanisms by which stem cells create the improvements seen.

These results raise the hope that transplantation of BDNF-producing neural stem cells may offer a new approach for treating Lewy Body Dementia and other neurodegenerative conditions.

Although stem cell therapy is currently not yet improved by the FDA for general medical use in the Untied States, the treatment is available to the public through practitioners utilizing IRB approved research protocols.

To learn more about Stem Cell Therapy please view the  information available at

Regenerative Medicine/Stem Cells

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

 

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