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Study Shows How Green Tea Helps Combat Obesity and Dementia

Study Shows How Green Tea Helps Combat Obesity and Dementia

The latest thinking about dementia in the scientific community is that cognitive impairment can be seen as “Diabetes Type 3”, because an abnormal handling of glucose in the brain seems to be one of the underlying mechanisms which promotes dementia, just as impaired glucose regualton in the body is an essential component of the common disorder known as Diabetes Type 2.

A study published by the Federation of American Societies for Experimental Biology  shows that drinking green tea may help fight brain glucose dysregulation, obesity and memory impairment. The mechanism involved was studied in mice. It shows that the active ingredient in green tea, EGCG (epigallocatechin-3-gallate), alleviates the effects of a high-fat and high-fructose diet  known to promote cognitive impairment. Researcher Xuebo Liu, Ph.D.,of the  Northwest A&F University in Yangling, China says, “Green tea is the second most consumed beverage in the world after water, and is grown in at least 30 countries, “The ancient habit of drinking green tea may be a more acceptable alternative to medicine when it comes to combatting obesity, insulin resistance, and memory impairment.”

In this study groups of mice were fed differing diets for 16 weeks, and the effects of those given the active ingredient in green tea, ( EGCG ) were shown to score better on performance of tasks which measure their ability to complete remember and thus perform a task, navigating a maze.

There have been a number of research reports regarding green tea’s health benefits in the  past,  and with regard to this study Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal

says, “Many reports, anecdotal and to some extent research-based, are now greatly strengthened by this more penetrating study.”



Weight Loss Puts Diabetes in Remission in Less Than One Year!

Weight Loss Puts Diabetes in Remission in Less Than One Year!

Just published research from Britain shows that for people with Diabetes Type 2, weight loss can put the disease into remission when the weight loss is maintained.

After 1 year, one half of the study participants reverted to a non-diabetic state without using any diabetes drug treatment. Professor Michael Lean from the University of Glasgow says, “Our findings suggest that even if you have had type 2 diabetes for 6 years, putting the disease into remission is feasible. In contrast to other approaches, we focus on the need for long-term maintenance of weight loss through diet and exercise.” Co-author of the study  Professor Roy Taylor of Newcastle University comments on how medical practitioners do not give dietary treatment the emphasis it deserves. “Rather than addressing the root cause, management guidelines for type 2 diabetes focus on reducing blood sugar levels through drug treatments. Diet and lifestyle are touched upon, but diabetes remission by cutting calories is rarely discussed.”

The study is called the Diabetes Remission Clinical Trial (DiRECT), and has just been published in the British Medical Journal Lancet. The study subjects were  298 adults aged 20-65 years who had been diagnosed with type 2 diabetes. A weight loss of  30 lbs or more was shown to be sufficient to achieve a  remission of diabetes in the majority of cases. Remission was defined as achieving Hgb A1C reading of level of less than 6.5% at 12 months,off all medications.

The study also revealed that 2 more health benefits shown by their data was an improvement in average triglyceride levels , and that almost half the participants with high blood pressure were able to discontinue antihypertensive drugs with no rise in blood pressure. And finally, by recording quality of life measurements, a substantially improved quality of life was reported at 12 months.

Professor E.M. Uusitupa who authored a commentary to the published study concludes that the efidence provided from this and other studies indicates that  “… weight loss should be the primary goal in the treatment of type 2 diabetes.”

For the best care in Weight Control Medicine contact our office at 203-348-8805


Weight Loss Can Slow Knee Joint Degeneration

Weight Loss Can Slow Knee Joint  Degeneration
Obesity increases the risk of osteoarthritis. Being overweight places extra pressure on joints and cartilage, causing them to degenerate over time.

              According to a new study published online in the journal Radiology, overweight  people who lost a substantial amount of weight over a 48-month period showed significantly lower degeneration of their knee cartilage.

“This study’s lead author, Alexandra Gersing, M.D., of  the Department of Radiology at the University of California, San Francisco, explained, “We looked at the degeneration of all knee joint structures, such as menisci, articular cartilage and bone marrow.”

The research team investigated the possible influence of  weight loss on the progression of cartilage changes in the knee, that could be assessed by MRI studies. Data collected  from this study showed that over a 4 year study period, the 640 overweight patients who were a part of their study, were able to  reduce the progression of osteoarthritis of the knee with weight reduction. They were also able to show that greater weight reduction helped more than more modest weight loss. Patients were categorized into three groups: those who lost more than 10 percent of their body weight, those who lost five to 10 percent of their body weight, and a control group whose weight remained stable.

The results showed that patients with 5 percent weight loss had lower rates of cartilage degeneration, and also that in those with over 10 percent weight loss, cartilage degeneration was even slower.

“Dr. Gershing found that , “The most exciting finding of our research was that not only did we see slower degeneration in the articular cartilage, we saw that the menisci degenerated a lot slower in overweight and obese individuals who lost more than 5 percent of their body weight, and that the effects were strongest in overweight individuals and in individuals with substantial weight loss.”  It is the loss of cartilage and the damage to the meniscus of the knee and the bony damage to the joint that leads to the necessity of orthopedic interventions including not only steroid injections but knee replacement surgery. An exciting new field of Regenerative Medicine is growing in which natural ways to heel the joints include PRP and Stem Cell Therapy.

For more information on these treatments offered by Dr. Sobo see these links.

PRP for Knees, Other Joints, Tendons


Cinnamon Helps Fight Fat

Cinnamon Helps Fight Fat

Newly published research from the University of Michigan Life Sciences Institute shows that cinnamon may help your metabolism in the fight against excess body weight.

Their study is entitled Cinnamaldehyde Induces Fat cell-autonomous Thermogenesis and Metabolic Reprogramming. Cinnamaldehyde is  an essential oil that gives cinnamon its flavor, and it now appears that it may help in the fight against appears against obesity.

Researcher Jun Wu, discussing their study says, “Scientists were finding that this compound affected metabolism, so we wanted to figure out how — what pathway might be involved…in human cells.” This study, published in the December issue of the scientific journal Metabolism shows that the essential oil in cinnamon called cinnamaldehyde improves metabolic activity of fat cells causing them to start burning fat and energy through a process called thermogenesis. Fat cells store energy in the form of lipids. When the cells were treated with cinnamaldehyde, the researchers noticed increased expression of several genes and enzymes that enhance lipid metabolism. “Cinnamon has been part of our diets for thousands of years, and people generally enjoy it, so if it can help protect against obesity, too, it may offer an approach to metabolic health that is easier for patients to adhere to.”

This is the time of year when many Americans eat excess calories and expand their waistline- adding cinnamon to foods during the holiday season may help limit the extra pounds put on during the holiday season.


Consuming Antioxidant Foods Lowers Diabetes Risk

Consuming Antioxidant Foods Lowers Diabetes Risk

A study from France has shown that a diet rich in anti oxidant foods lowers the risk of Diabetes Type 2.
This kind of diet has already been shown to lower the risk of developing certain types of cancers and so this study ads to the proven benefits of eating a healthy diet. The study subjects were over 64,000 French women between 40 and 65 years, surveyed from 1993 to 2008. Each study subject completed a dietary questionnaire at the beginning of the study, including detailed information on their intake of more than 200 different foods. Putting this information together with previously established measures of the anti oxidant content of different foods, gave the researchers the data they needed to calculate a score for ‘total dietary antioxidant capacity’ for each participant.

Their results show that the risk of diabetes diminishes with greater antioxidant consumption. Some of the antioxidant-rich foods that made the difference were dark chocolate, tea, walnuts, prunes, blueberries, strawberries and hazelnuts. Women with the greatest antioxidant scores had a reduction in diabetes risk of 27% compared with those with the lowest scores. Researcher Francesca Romana Mancini says, “This link persists after taking into account all the other principal diabetes risk factors: smoking, education level, hypertension, high cholesterol levels, family history of diabetes and, above all, BMI, the most important factor” The foods and drinks that contributed the most to a high dietary antioxidant score were fruits and vegetables, tea and red wine (consumed in moderate quantities).”
Lead researcher Guy Fagherazzi, explains “This work complements our current knowledge of the effect of isolated foods and nutrients, and provides a more comprehensive view of the relationship between food and type 2 diabetes. We have shown that an increased intake of antioxidants can contribute to a reduction in diabetes risk’.

For more of the latest in nutritional/ lifestyle research check all of my blog posts at

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at


Injection of Stem Cells for Arthritis of the Knee Shows Benefit in 2 Year Follow-up Study

Injection of  Stem Cells for Arthritis of the Knee Shows Benefit in 2 Year Follow-up Study

In patients with osteoarthritis of joints, the injection of mesenchymal stem cells (MSCs) into the affected joint is becoming increasingly recognized as a safe and effective treatment. Stem cell therapies are becoming more widespread due to their effectiveness, as well as the lack of side effects or complications seen  with properly done stem cell treatments. Stem cell therapy has been shown to improve not only the symptoms of arthritis, but it also can improve and grow cartilage. Loss of cartilage within the joint is a characteristic of osteoarthritis.  A newly published study in this field was done at the Department of Orthopedic Surgery at the  National University College of Medicine, in  Seoul, South Korea . Their study showed showed that stem cell treatment of osteoarthritis of the knee provides positive effects that were relatively long lasting, measured at the 2 year mark in this study .

Eighteen patients with Osteoarthritis of the knee were enrolled in the study, with an average age of 61.8 years, with all participants being between 52 and 72 years old.

To assess the effects of the stem cell treatment, the researchers used the well recognized WOMAC scale, which evaluates the following; 1- pain 2- stiffness and 3- difficulty performing daily activities. They also used the  KOOS score (Knee injury and Osteoarthritis Outcome). Physical changes were assessed  using an MRI study to measure  the size and depth of the cartilage defect,  and cartilage volume, which is reduced in knee osteoarthritis. Improvements were seen both in the symptoms-pain , stiffness, and physical activity limitations, as well as in healing and improvement in the cartilage defects associated with the condition.  This study also documented that there were no treatment related side effects reported by any of the patients in the study. The conclusion of their study supports the use of stem cell therapy for osteoarthritis of the joints.

For the best care in Anti-Aging and Regenerative Medicine Integrative Medicine please see our website at

For an appointment call Dr. Henry C. Sobo, M.D., at 203-348-8805 or write us at




Yale Studies Food Sensitivity Testing for Irritable Bowel Syndrome

Yale Studies Food Sensitivity Testing for Irritable Bowel Syndrome
Yale University has just published a study in the British Medical Journal which shows that patients with Irritable Bowel Syndrome who follow diets based on food sensitivity testing improve, having fewer and less severe symptoms.
Irritable bowel syndrome (IBS) is a disorder that can cause gas, abdominal pain, and either diarrhea, constipation or both.
A double-blind study of 58 patients was performed. Blood samples were used to measures immune cell activation in response to many foods. The study participants were then placed on individualized diets that restricted the intake of the foods the subjects showed sensitivity to.
After several weeks the study participants were assessed for their IBS symptoms.They found that participants who restricted their intake of offending foods improved more than those given general dietary instructions.This study provides scientific evidence for this medication-free approach, which may lead to further recognition in the medical community of the importance of food sensitivity testing.
Amazingly the lead researcher Ather Ali said was quoted as saying,
“We didn’t expect results like this.” Why this was so surprising is unclear, but unfortunately may reflect a bias in medicine against dietary / natural treatments compared to drug treatments used for most conditions in medical practice today.
Hopefully the credibility that a Yale study may lend to this drug free appraoch will encourage more physicians to take an interest in food sensitivity testing for their patients.




Sharp Again Naturally works to educate individuals, their families and medical professionals about causes of memory loss and dementia that can be prevented and treated.   For more information about Sharp Again Naturally, go to


HONEYBRAINS AT 372 Lafayette St. NYC Tuesday, July 11, 2017 6:30 – 9:00 PM

A 2 minute video on Honeybrains:


DR Sobo is a Medical Advisory Board member at Sharp Again Naturally and he hopes to see you there !


Space is limited at this hip downtown eatery, so please RSVP early. Tickets are $125.  If you are unable to attend and would like to make a contribution, click here.