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New Study Says Brain Damage Caused by Stroke May Heal with Stem Cells

New Study Says Brain Damage Caused by Stroke May Heal with Stem Cells

Researchers from the University of Georgia’s Regenerative Bioscience Center, published a study in the scientific journal Translational Stroke Research, which shows that the brain damage caused by a stroke may be healed by stem cells. This study used a substance they called AB126 generated from nervous system stem cells. The healing factors are contained in “exosomes” which are tiny vesicles inside stem cells which secrete proteins which help the healing process. This research is an animal study which is preliminary to the next step, human studies. Researcher Steven Stice says, “This is truly exciting evidence, because exosomes provide a stealth-like characteristic, invisible even to the body’s own defenses. When packaged with therapeutics, these treatments can actually change cell progression and improve functional recovery.”

After giving the AB126,  MRI scans of the brain were performed and they revealed a very large decrease in the amount of brain tissue which was damaged. A start up company called ArunaA Biomedical is preparing to launch of human study in 2019. Dr Strice explains, “Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function. Just days after stroke, we saw better mobility, improved balance and measurable behavioral benefits in treated animal models.”

 

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Mediterranean Diet Slows the Development of Frailty in the Elderly

Mediterranean Diet Slows the Development of Frailty in the Elderly

A new study published in the Journal of the American Geriatrics Society, provides more evidence that following what is called the Mediterranean diet may slow aging. Eating mostly plant-based foods  such as whole grains, legumes, nuts, and  fruits and vegetables, reduces the risk of frailty in older individuals keeping them healthier and more independent as they age.

Frailty Syndrome is a term which refers to older individuals who manifest decreased muscle strength, low energy, weight loss and associated problems like increased susceptibility to falls and fractures. This study ads credence to the notion that the diet may play an important role in the development of frailty, or its avoidance as one ages.

This research paper analyzed the  evidence available from many studies which have examined the possible health benefits of the Mediterranean diet. In total the analysis included nearly 5,800 people from a number of countries.

Researcher Kate Walters, PhD of University College London, in the UK, says, “We found the evidence was very consistent that older people who follow a Mediterranean diet had a lower risk of becoming frail. People who followed a Mediterranean diet the most were overall less than half as likely to become frail over a nearly four-year period compared with those who followed it the least.”

This study found  that the Mediterranean diet may help older individuals maintain muscle strength, activity, weight, and energy levels. Research colleague Dr. Gotaro Kojima ads, “Our study supports the growing body of evidence on the potential health benefits of a Mediterranean diet, in our case for potentially helping older people to stay well as they age.”

More and more research continues to show that diet, nutrition and lifestyle are key components for any anti- aging program.

 

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Sitting Too Long Is Bad For Your Health

Sitting Too Long Is Bad For Your Health

Newly published research in the journal Obesity provides further evidence of the negative health consequences of inactivity. Researchers from the University of Leicester and Loughborough University in the UK shows that being sedentary is associated with greater deposition of fat around the internal organs. This has long been known to increase the risk of cardiovascular disease.

This study utilized 124 subjects at high risk of type 2 diabetes, and measured the length of time they spent sedentary over a 7 day period. The study subjects had MRIs done to measure  the amount of fat in the liver, visceral fat around other organs, and total abdominal fat. Their data found that the longer a person remained sedentary during the day, the higher the levels of liver fat, inner (visceral) fat and total abdominal fat.

Dr Joe Henson of the University of Leicester, says, “We know that spending long periods of time sedentary is unhealthy and a risk factor for chronic illnesses, such as type 2 diabetes and heart disease. Likewise, the amount of fat deposited around our internal organs may also predispose us to these diseases. Using MRI techniques and physical activity monitors we have shown that the more time spent sedentary, the stronger the association with higher levels of internal and abdominal fat. This was particularly so if the long periods of sedentary behaviour were uninterrupted. Our findings also show that reaching the UK government’s target of 150 minutes of moderate intensity physical activity may offer some protection against the harmful effects of prolonged sedentary time.”

For more information on healthy weight reduction plans see http://drsobo.com/therapeutic-services/weight-loss/

 

 

 

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Junk Food Disorders the Immune System

Junk Food Disorders the Immune System

       A study led by the University of Bonn, published in the journal CELL shows that the immune system responds to a high fat and high calorie diet in a  way similar to its response to a bacterial infection. In this study 120 mice were the subjects . They were placed on a “Western diet”, high in fat, high in sugar, and low in fiber for four weeks. Researcher Anette Christ, of the Institute of Innate Immunity  explains,”The unhealthy diet led to an unexpected increase in the number of certain immune cells in the blood of the mice.”

 When the researchers placed the mice back on their typical cereal of cereal for another  four weeks, some of the acute inflammatory responses abated . However, what was particularly disturbing was that did not go away was the genetic reprogramming of  immune cells, so that the immune system abnormalities that had been switched on during the fast food phase of the study still had abnormal activity, and these inflammatory responses can be  a part of  the development of vascular diseases or type 2 diabetes or other diseases. Underlying inflammatory responses are increasingly being viewed as the culprit for many if not most of modern society’s chronic diseases. Researcher Eicke Latz concludes…”These findings therefore have important societal relevance. The foundations of a healthy diet need to become a much more prominent part of education than they are at present.”

This study is yet another piece of scientific evidence that disease prevention begins with a proper diet.

 

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Stem Cells for Knee Osteoarthritis

Stem Cells for Knee Osteoarthritis

A small study from the University of Belgrade School of Medicine, assessed nine patients who received stem cell injections for arthritis of the knee.

They followed these patients for eighteen months. The results were the following:

Improvement in the clinical scores of pain and disability, and radiographic studies, were found within the first six  months . And the improvement was still seen at the study’s end eighteen months later. To assess the status of the knee they used the following four methods of observation of knee health. 1. X rays , 2. MRIs , 3.Pain scores , and 4. Quality of Life scores.

 All of the nine study subjects had osteoarthritis of the Knee, and received a single joint injection of adipose derived  autologous mesenchymal stem cells.

The data showed significant improvement in all four clinical scores. The MRI studies were able to show restoration of cartilage by the measurement of a greater volume of cartilage within the treated knee at the end of the study in comparison to what existed before treatment. The authors concluded that their results provides a good basis for more clinical trials to assess the use of Stem Cell Therapy for Osteoarthritis of the knee.

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Vitamin D Reduces Arterial Stiffness, May Prevent Heart Disease

Vitamin D Reduces Arterial Stiffness, May Prevent Heart Disease

Research has shown that Vitamin D has  protective effects against many common disorders, including cardiovascular disease. Now, a new research report may tell us why that is the case. This study from the Medical College of Georgia showed that after taking 4,000 IU of vitamin D for 4 months , measures of arterial stiffness were reduced in young, overweight, vitamin D deficient African-Americans . The skin makes vitamin D in response to sun exposure, and darker skin absorbs less sunlight, imparting a greater risk of Vitamin D deficiency to the African American population.

Rigidity of the arterial system predicts the risk of cardiovascular- related disease. Dr. Arnas Raed from the medical school’s Dept. of Medicine explains, “When your arteries are more stiff, you have higher pulse wave velocity, which increases your risk of cardiometabolic disease in the future.”

Dr. Raed, research resident from the Medical College of Georgia’s Department of Medicine, and the study’s lead author states that his data regarding Vitamin D supplementation showed that taking 4,000IU of Vitamin,”… significantly and rapidly reduced stiffness.” Research subjects who had taken 2,000 IU per day  also a reduction in arterial stiffness but it was not as significant as for those who took 4,000IU .

Vitamin D containing foods include dairy, fatty fish like sardines, some greens like kale. Another good source is fortified cereals. Finally Vitamin D supplement are an inexpensive option to make sure your taking in enough to make  a difference.

 

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Whole Eggs Superior to Egg Whites for Muscle Building

Whole Eggs Superior to Egg Whites for Muscle Building

The practice of throwing away the yolk and getting protein just from the white’s of eggs may be a mistake. This discovery just published in the American Journal of Clinical Nutrition, suggests that the post-workout muscle-building response to eating a whole egg may be 40 percent greater than the response to consuming an equivalent amount of protein from just egg whites.

Professor Nicholas Burd lead researcher from the University of Illinois-Urbana-Champaign which produced the study says, “This study suggests that eating protein within its most natural food matrix tends to be more beneficial to our muscles as opposed to getting one’s protein from isolated protein sources. ” He explains that ,” the yolks also contain protein, along with key nutrients and other food components that are not present in egg whites.” It seems that something contained within the yolk enhances the body’s ability to utilize the protein to build muscle.

In this study, 10 young men engaged in resistance exercise and then ate either whole eggs or egg whites . The researchers then took repeated blood and muscle biopsy samples to assess how the egg-derived amino acids were appearing in the blood and in protein synthesis in muscles before and after the resistance exercise and eating.

Dr Burd says that his study data revealed that, “if you ate the whole egg or the egg whites, the same amount of dietary amino acids became available in your blood,…but…the ingestion of whole eggs resulted in greater muscle-protein synthesis than the ingestion of egg whites”.

With the increasing sales of items like protein shakes, used by so many  workout enthusiasts, this may be another example where mother nature’s whole food outperforms a supplement.

 

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Eating Fish Linked to Higher IQ and Better Sleep

Eating Fish Linked to Higher IQ and Better Sleep

Another study confirms that fish consumption in children is linked to important health benefits.

Past studies  have indicated a beneficial association between fish consumption and cognition. Other studies have shown that fish consumption helps sleep.  This  newly published study from the University of Pennsylvania as reported in the journal Scientific Reports, seems to link these benefits. It shows that children who eat fish weekly have better sleep patterns, and score better on IQ tests well.

Nutritionally, the intake of omega-3 fatty acids found in many types of fish, has been found to be associated with improvement in both intelligence test scores as well as being associated with better sleep. The authors of this study believe that better sleep may be a mediator- the potential missing link between eating fish and intelligence score improvements.

Researcher  A. Raine explains, “Lack of sleep is associated with antisocial behavior; poor cognition is associated with antisocial behavior. We have found that omega-3 supplements reduce antisocial behavior, so it’s not too surprising that fish is behind this.”

Over  f5,000  9 to 11-year-olds in China were the study subjects. They were surveyed for their frequency of fish consumption and their parents surveyed for their sleep habits. The children were then administered the  Wechsler Intelligence Scale for Children- the IQ test. Their data revealed that children who eat fish weekly scored 4.8 points higher on the IQ exams than those who said they “seldom” or “never” consumed fish. Their fish consumption was also associated with fewer sleep disturbances.

Pinto-Martin,executive director of Penn’s Center for Public Health Initiatives, comments on the implications of this research- “It adds to the growing body of evidence showing that fish consumption has really positive health benefits and should be something more heavily advertised and promoted. Children should be introduced to it early on.”  Consumption of fish  once per week moves a family into the “high” fish-eating group as defined in this study. “Doing that could be a lot easier than nudging children about going to bed,” Dr Raine says. “If the fish improves sleep, great. If it also improves cognitive performance – even better. It’s a double hit.”

 

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Study Shows How Green Tea Helps Combat Obesity and Dementia

Study Shows How Green Tea Helps Combat Obesity and Dementia

The latest thinking about dementia in the scientific community is that cognitive impairment can be seen as “Diabetes Type 3”, because an abnormal handling of glucose in the brain seems to be one of the underlying mechanisms which promotes dementia, just as impaired glucose regualton in the body is an essential component of the common disorder known as Diabetes Type 2.

A study published by the Federation of American Societies for Experimental Biology  shows that drinking green tea may help fight brain glucose dysregulation, obesity and memory impairment. The mechanism involved was studied in mice. It shows that the active ingredient in green tea, EGCG (epigallocatechin-3-gallate), alleviates the effects of a high-fat and high-fructose diet  known to promote cognitive impairment. Researcher Xuebo Liu, Ph.D.,of the  Northwest A&F University in Yangling, China says, “Green tea is the second most consumed beverage in the world after water, and is grown in at least 30 countries, “The ancient habit of drinking green tea may be a more acceptable alternative to medicine when it comes to combatting obesity, insulin resistance, and memory impairment.”

In this study groups of mice were fed differing diets for 16 weeks, and the effects of those given the active ingredient in green tea, ( EGCG ) were shown to score better on performance of tasks which measure their ability to complete remember and thus perform a task, navigating a maze.

There have been a number of research reports regarding green tea’s health benefits in the  past,  and with regard to this study Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal

says, “Many reports, anecdotal and to some extent research-based, are now greatly strengthened by this more penetrating study.”

 

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Weight Loss Puts Diabetes in Remission in Less Than One Year!

Weight Loss Puts Diabetes in Remission in Less Than One Year!

Just published research from Britain shows that for people with Diabetes Type 2, weight loss can put the disease into remission when the weight loss is maintained.

After 1 year, one half of the study participants reverted to a non-diabetic state without using any diabetes drug treatment. Professor Michael Lean from the University of Glasgow says, “Our findings suggest that even if you have had type 2 diabetes for 6 years, putting the disease into remission is feasible. In contrast to other approaches, we focus on the need for long-term maintenance of weight loss through diet and exercise.” Co-author of the study  Professor Roy Taylor of Newcastle University comments on how medical practitioners do not give dietary treatment the emphasis it deserves. “Rather than addressing the root cause, management guidelines for type 2 diabetes focus on reducing blood sugar levels through drug treatments. Diet and lifestyle are touched upon, but diabetes remission by cutting calories is rarely discussed.”

The study is called the Diabetes Remission Clinical Trial (DiRECT), and has just been published in the British Medical Journal Lancet. The study subjects were  298 adults aged 20-65 years who had been diagnosed with type 2 diabetes. A weight loss of  30 lbs or more was shown to be sufficient to achieve a  remission of diabetes in the majority of cases. Remission was defined as achieving Hgb A1C reading of level of less than 6.5% at 12 months,off all medications.

The study also revealed that 2 more health benefits shown by their data was an improvement in average triglyceride levels , and that almost half the participants with high blood pressure were able to discontinue antihypertensive drugs with no rise in blood pressure. And finally, by recording quality of life measurements, a substantially improved quality of life was reported at 12 months.

Professor E.M. Uusitupa who authored a commentary to the published study concludes that the efidence provided from this and other studies indicates that  “… weight loss should be the primary goal in the treatment of type 2 diabetes.”

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