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Alzheimer Brain May Be Helped By THC In Cannabis

Alzheimer Brain May Be Helped By THC In Cannabis

A study from the Salk Institute, supported by the National Institutes of Health has found evidence that THC (tetrahydrocannabinol)  and other compounds found in marijuana may promote the removal of amyloid beta, the toxic protein associated with Alzheimer’s disease.

Senior researcher  of the paper, Salk Professor David Schubert says, “Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,”

It is known that amyloid beta accumulates within the nerve cells of the aging brain and is a major component of the plaque deposits that characterize Alzheimer’s Disease.

In this study published in the June 2016 edition of  Aging and Mechanisms of Disease, Salk’s research team studied  laboratory mice whose nerve cells altered to produce high levels of amyloid beta to mimic Alzheimer’s disease. They showed that exposing the cells to THC reduced amyloid beta protein levels, and eliminated the inflammatory response from the nerve cells caused by the protein, preventing nerve cell death.

“Inflammation within the brain is a major component of the damage associated with Alzheimer’s disease,” says researcher Antonio Currais. “When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying.”

Lead author Schubert says that the use of THC-like compounds as a therapy would need to be tested in clinical trials  before nay treatment recommendations could be made by doctors to their patients.

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Progression of Macular Degeneration Slowed By Omega-3 Fatty Acids

Progression of Macular Degeneration Slowed By Omega-3 Fatty Acids

Age related Macualr Degeneration is a leading cause of vision loss and blindness in the U.S. and worldwide. Just published research from the Massachusetts Eye and Ear Infirmary showed that supplements of Omega 3-fayy acids inhibited the growth of blood vessels in the back of the eye as occurs in the development of macular degeneration. K. Connor, Ph.D., Professor of Ophthalmology at Harvard Medical School and senior author of the paper states, “These are the first results showing that omega (ω)-3 LCPUFAs and their CYP derived metabolites can regulate choroidal angiogenesis (growth of blood vessels-editor’s note)… “The fact that this can be accomplished with physiologically relevant naturally occurring lipid metabolites is of significant clinical interest as these molecules are readily available and considered to be safe. Our findings …show promising therapeutic potential for resolution of Macular Degeneration.” The authors also point out that the value of omega-3 fatty acids will likely extend to other heart and vascular problems which develop via similar mechanisms to that which occurs in macular degeneration.
The best food sources of the omega-3 fatty acids are found in a variety of foods. The richest food sources are fish, vegetables, and oils. There are also significant amounts of Omega-3s in lamb, veal, and legumes. And lesser amounts are also found in poultry, dairy and eggs, and also in nuts and seeds.

For the best in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhealth@optonline.net

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