All posts in Anti-Aging

Brains of Overweight People ‘Ten Years Older’ Study Shows

Brains of Overweight People ‘Ten Years Older’ Study Shows

The team studied data from 473 individuals between the ages of 20 and 87, at the Cambridge Centre for Aging and Neuroscience.

Research study author Dr Lisa Ronan says, “As our brains age, they naturally shrink in size, but it isn’t clear why people who are overweight have a greater reduction in the amount of white matter. We can only speculate on whether obesity might in some way cause these changes… ”

Senior author Professor Paul Fletcher, says “We’re living in an aging population, with increasing levels of obesity, so it’s essential that we establish how these two factors might interact, since the consequences for health are potentially serious. It will also be important to find out whether these changes could be reversible with weight loss, which may well be the case.”

For more of the latest in nutritional/ lifestyle research check all of my blog posts at www.drsobo.com/blog

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

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Nut Consumption Reduces Inflammation

Nut Consumption Reduces Inflammation

A new study published in American Journal of Clinical Nutrition showed that dietary intake of nuts is associated with lower levels of the biomarkers of inflammation. This study of than 5,000 people by the  Brigham and Women’s Hospital  may help to explain the documented health benefits of nuts.

Research study author Ying Bao M.D. ScD, says, “Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases. Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.”

For this study, the research team performed  an analysis of data using dietary questionnaires, comparing the levels of the  proteins known as biomarkers in blood samples collected from the study subjects. The biomarkers of inflammation that were affected were, C-reactive protein (CRP) and interleukin 6 (IL6) .

The data revealed that those who had consumed at least five  servings of nuts per week had lower levels of CRP and IL6 than those who rarely or almost never ate nuts. Dr Bao says, “Much remains unknown about how our diet influences inflammation and, in turn, our risk of disease. But our study supports an overall healthful role for nuts in the diet and suggests reducing inflammation as a potential mechanism that may help explain the benefits of nuts on cardiometabolic diseases.”

For more of the latest in nutritional/ lifestyle research check all of my blog posts at www.drsobo.com/blog

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net



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Negative Beliefs About Aging May Promote Development of Alzheimer’s

Negative Beliefs About Aging May Promote Development of  Alzheimer’s

New research from the Yale School of Public Health finds an association between holding negative or pessimistic beliefs about aging and the development of brain changes associated with Alzheimer’s disease.

Brain changes were studied in both live persons with MRI scans, and deceased study subjects by autopsy.

This study is the first to link the brain changes of Alzheimer’s disease to a  psychosocial risk factor.

Study author Becca Levy professor of Public Health and Psychology at Yale University states, “We believe it is the stress generated by the negative beliefs about aging that individuals sometimes internalize from society that can result in pathological brain changes. Although the findings are concerning, it is encouraging to realize that these negative beliefs about aging can be mitigated and positive beliefs about aging can be reinforced, so that the adverse impact is not inevitable.”

The study suggests that part of an Alzheimer’s prevention program  may involve combatting negative stereotypes about aging. If it is widely understood that having pessimistic views about the elderly may become a self fulfilling prophecy by promoting dementia, it may offer a way to slow the rapidly rising rate of Alzheimer’s disease which now affects over 5 million Americans.

Using MRI scans in living individuals, the research found that subjects who held more negative beliefs about aging showed  greater shrinkage of  a part of the brain crucial to memory called the hippocampus. The hippocampus is known to be smaller in Alzheimer’s disease.

Brain autopsies which were performed showed that two well established indicators Alzheimer’s disease, amyloid plaques and neurofibrillary tangles ,were worse in those who had by survey expressed more negative beliefs about aging. This study was published in the September issue of journal Psychology and Aging.

Follow Dr. Sobo’s Alzheimer’s/ Dementia Research Blog at

http://drsobo.com/category/alzheimers-dementia/

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Moderate coffee drinking linked to reduced risk of death

Moderate coffee drinking linked to reduced risk of death

A study funded by The National Institutes of Health reported  in the medical Journal Circulation shows that people who regularly drink moderate amounts of coffee daily -less than 5 cups per day – lower their risk of death from cardiovascular and neurological diseases, as well as  Type 2 diabetes .

Drinking either caffeinated or decaffeinated coffee was beneficial which suggests that it’s not the caffeine in coffee which is beneficial, but the antioxidants found in coffee beans. Ming Ding, M.D. one of the  the study’s author’s explains, “Bioactive compounds in coffee reduce insulin resistance and systematic inflammation.”

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Low Vitamin D In The Elderly Associated With More Rapid Development of Dementia, Alzheimer’s

Low Vitamin D In The Elderly Associated With More Rapid Development of Dementia, Alzheimer’s

According to research from the UC Davis Alzheimer’s Disease Center, elderly individuals with low vitamin D levels show a decline in cognitive functions a a rate three times faster than those with sufficient vitamin D levels.

Joshua Miller, MD lead author of the research  published in JAMA Neurology says, “Independent of race or ethnicity, baseline cognitive abilities and a host of other risk factors, vitamin D insufficiency was associated with significantly faster declines in both episodic memory and executive function performance… This work, and that of others, suggests that there is enough evidence to recommend that people in their 60s and older discuss taking a daily vitamin D supplement with their physicians”.

The study included nearly 400 men and women of varied racial and ethnic backgrounds living in Northern California with a mean age of 76. They were followed for a period of five years. At the start the study subjects were classified as being cognitively normal, had mild cognitive impairment or had dementia. The participants’ serum vitamin D status was measured at the beginning of the study, and after five years of follow-up, the vitamin D deficient individuals had a progression of cognitive decline that was up three times faster than those with adequate  vitamin D levels.

Charles DeCarli, director of the Alzheimer’s Disease Center explains, “We expected to see declines in individuals with low vitamin D status. What was unexpected was how profoundly and rapidly low vitamin D impacts cognition. I don’t know if replacement therapy would affect these cognitive trajectories. That needs to be researched and we are planning on doing that.This is a vitamin deficiency that could easily be treated and that has other health consequences. We need to start talking about it, particularly for people of color, for whom vitamin D deficiency appears to present an even greater risk,” he said.

Vitamin D is made when the skin is exposed to sunlight. Foods with high content of Vitamin D are oily fish such as salmon and sardines, eggs, and fortified cereals.

For more information about Dr Sobo’s treatment protocols for Alzheimer’s / Dementia, please see our website

For more of the latest in nutritional/ lifestyle research check all of my blog posts at www.drsobo.com/blog

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

 

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Study Shows Memory Loss of Alzheimer’s Improved By Lifestyle Changes, Supplements

Study Shows Memory Loss of Alzheimer’s Improved By Lifestyle Changes, Supplements

A  study published in the online edition of the journal Aging, reported that nine out of ten participants who followed a comprehensive anti-aging program to reverse memory loss showed signs of improvement at three and six months.

Six  of the ten who had reported that they had discontinued working because of their cognitive impairment or had been struggling at work, were all were able to return to work or continue at their jobs with improved performance. Those in the study with relatively milder cognitive impairment fared better. One patient in the study  who was classified as having late stage Alzheimer’s Disease did not improve.

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Testosterone Therapy: “Significant Reduction” in Heart Attack, Stroke Risks

Testosterone Therapy: “Significant Reduction” in Heart Attack, Stroke Risks

A United States  Veterans Affairs  study of greater than 83,000 men found  that men who had  low testosterone levels and received treatment, significantly lower their  risk of heart attack and stroke, or death from any cause. If the men’s testosterone levels were restored to normal, then a dramatic reduction of 56% in the overall death rate was seen in comparison to men whose low testosterone level was never treated . Treatment was found to be effective whether the testosterone prescribed as given via injections, gels, or patches.

There was also a benefit of lesser degree shown in the group of men who were treated with testosterone, but  did not  raise their testosterone levels to normal as shown in repeat testing- their levels were improved but still low.

The study used a follow-up period of from 4.6 to 6.2 years to asses the incidence of illness and deaths reported over that time period.

It was also found that men successfully treated with testosterone  (levels normalized), lowered their incidence of having  a heart attack by  24% and lowered their stroke risk by 36%.

For more of the latest in nutritional/ lifestyle research check all of my blog posts at www.drsobo.com/blog

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

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Anti-Aging Healthy Lifestyle

Anti-Aging Healthy Lifestyle

The following is adapted from lectures given by Dr. Sobo at the Wainwright House in Rye, N.Y. and the Total Life Care Center in Norwalk, CT.

Theories of Aging

There are two basic types:

  1. Genetically programmed aging: Telemorase Theory
  2. Progressive damage aging: Free Radical Theory and Neuroendocrine Theory
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Stem Cell Discoveries Pave The Way For Improved Treatment of Osteoarthritis, Other Disorders

Stem Cell Discoveries Pave The  Way For Improved Treatment of Osteoarthritis, Other Disorders

The future is here ! Treating a variety of conditions with stem cells is a subject of intense investigation with hundreds  of  research studies being conducting all around the world. The hope is that stem cell therapy can help autoimmune diseases, neurologic disorders, diabetes, heart disease, the ravages of aging, and many other medical conditions.

A new study from the  Departments of Biology and Physics at York, which  was funded by Arthritis Research UK , has been published in the the journal Stem Cell Reports. They report having identified individual stem cells that can regenerate tissue, cartilage and bone. This knowledge opens the way to having  better treatment for arthritis. Many clinical practitioners utilizing these therapies in advance of their general approval by the medical community report that they have helped many people avoid joint replacement surgery.

Lead researcher Dr Paul Genever  says, “While stem cell therapy is an exciting new development for the treatment for osteoarthritis, up to now it has been something of a lottery because we did not know the precise properties of each of the cells. This project has helped us to establish which cells are good at regenerating tissue, cartilage and bone respectively. It will help in the search to develop more targeted therapies for arthritis patients.”

Dr James Fox one of the co-authors says, “Working with colleagues across the Arthritis Research UK Tissue Engineering Centre will help to bring our discovery closer to patient treatment.”

Director of Research at  Arthritis Research UK Dr Stephen Simpson tells us that “There are 8 million people in the UK living with the pain and disability caused by osteoarthritis. We are fighting to find better treatments and one day, a cure. This research is exciting and promising. Identifying specific stem cells that could help the damaged joint to repair itself, takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis.”

For more of the latest in nutritional/ lifestyle research check all of my blog posts at www.drsobo.com/blog

For the best care in Integrative Medicine call Henry C. Sobo, M.D., at 203-348-8805 or write us at optimalhalth@optonline.net

 

 

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Obesity, Insulin Resistance Increases Risk for Alzheimer’s Disease

Obesity, Insulin Resistance Increases Risk for Alzheimer’s Disease
A new study published in the Journal of the American Medical Association Neurology  finds a strong association between insulin resistance and decline in memory function, and the development of Alzheimer’s disease. The fact that obesity increases the risk of heart disease and some cancers is well known, but this study alerts us that the risk of memory loss is also a consequence we need to understand and act upon. Insulin resistance is common in people who are obese or pre-diabetic .
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